멘토정보

멘토 정보 표 - 멘토 성명, 직급, 전공, 연구분야 안내
성명 이윤미
직급 선임연구원
전공

약품화학

연구분야 한약재 및 한약 처방의 효능 평가

주요 연구실적

논문

주요 연구 실적 표-주요 연구실적에 대하여 연도, 논문명, 비고 안내
연도 논문명
2018 Aster Koraiensis extract and chlorogenic acid inhibit retinal angiogenesis in a mouse model of oxygen-induced retinopathy
2017 Jaeumganghwa-Tang, a traditional herbal formula, improves muscle function and attenuates muscle loss in aged mice
2017 Effects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice
2017 Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts
2016 Cnidium officinale extract and butylidenephthalide inhibits retinal neovascularization in vitro and in vivo
2016 Esculetin, a Coumarin Derivative, Inhibits Aldose Reductase Activity in vitro and Cataractogenesis in Galactose-Fed Rats.
2016 Extract of Polygonum cuspidatum Attenuates Diabetic Retinopathy by Inhibiting the High-Mobility Group Box-1 (HMGB1) Signaling Pathway in Streptozotocin-Induced Diabetic Rats.
2015 Litsea japonica extract inhibits neuronal apoptosis and the accumulation of advanced glycation end products in the diabetic mouse retina
2015 Vaccinium myrtillus extract prevents or delays the onset of diabetes–induced blood–retinal barrier breakdown
2015 Anti-glycation and anti-angiogenic activities of 5'-methoxybiphenyl-3,4,3'-triol, a novel phytochemical component of Osteomeles schwerinae
2015 Inhibitory effect of Samul-tang on retinal neovascularization in oxygen-induced retinopathy
2015 Litsea japonica Extract Inhibits Aldose Reductase Activity and Hyperglycemia-Induced Lenticular Sorbitol Accumulation in db/db Mice.
2015 OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats.
2015 Effect of Guibi-Tang, a Traditional Herbal Formula, on Retinal Neovascularization in a Mouse Model of Proliferative Retinopathy
2015 Cinidium officinale and its Bioactive Compound, Butylidenephthalide, Inhibit Laser-Induced Choroidal Neovascularization in a Rat Model
2015 Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae
2014 HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr−/− mice
2014 Sipjeondaebo-tang inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
2014 Aminoguanidine Protects against Apoptosis of Retinal Ganglion Cells in Zucker Diabetic Fatty Rats
2014 Root of Polygonum cuspidatum extract reduces progression of diabetes-induced mesangial cell dysfunction via inhibition of platelet-derived growth factor-BB (PDGF-BB) and interaction with its receptor in streptozotocin-induced diabetic rats
2014 Expression of heat shock protein 90 in the kidneys of diabetic db/db mice
2014 Extract of Cassiae semen attenuates diabetic nephropathy via inhibition of advanced glycation end products accumulation in streptozotocin-induced diabetic rats
2013 Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo
2013 Polygonum cuspidatum inhibits pancreatic lipase activity and adipogenesis via attenuation of lipid accumulation
2013 Scopoletin Inhibits Rat Aldose Reductase Activity and Cataractogenesis in Galactose-Fed Rats
2013 한국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (VIII)
2013 중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (VII)
2013 The Extract of Litsea japonica Reduced the Development of Diabetic Nephropathy via the Inhibition of Advanced Glycation End Products Accumulation in db/db Mice
2013 Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats
2013 2",4" -O-Diacetylquercitrun, a Novel Advanced Glycation End-Product Formation and Aldose Reductase Inhibitor from Melasrtoma sanguineum
2013 Effect of KIOM-79 on diabetes-induced myocardial fibrosis in Zucker Diabetic Fatty Rats.
2013 Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit AGE Formation and AR In Vitro and Vessel Dilation in Larval Zebrafish In Vivo
2013 한국약용식물의 최종당화산물 생성저해활성 검색 (IX)
2013 중국 약용식물의 최종당화산물 생성저해활성 검색 (X)
2013 Extract of Litsea japonica ameliorates blood-retinal barrier breakdown in db/db mice.
2013 Ethyl pyruvate inhibits retinal pathogenic neovascularization by downregulating HMGB-1 expression
2012 Methylglyoxal induces hyperpermeability of the blood-retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases.
2012 Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities.
2012 Inhibitory Activities of Cudrania tricuspidata Leaves on Pancreatic Lipase in vitro and Lipolysis in vivo
2012 KIOM-79 Protects AGE-Induced Retinal Pericyte Apoptosis via Inhibition of NF-kappaB Activation In Vitro and In Vivo
2012 Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress.
2012 Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products Formation (VII)
2011 Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts
2011 Galloyl glucoses from the seeds of Cornus officinalis with inhibitory activity against protein glycation, aldose reductase, and cataractogenesis ex vivo
2011 Preventive effect of chlorogenic acid on lens opacity and cytotoxicity in human lens epithelial cells
2011 중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (V)
2011 Quercitrin gallate inhibits aldose reductase activity and xylose-induced lens opacity and oxidation
2011 Inhibitory Effects of Chlorogenic Acid on Aldose Reductase Activity In Vitro and Cataractogenesis in Galactose-fed Rats
2011 Chlorogenic acid inhibits the formation of advanced glycation end products and associated protein cross-linking.
2011 중국약용식물의 최종당화산물 생성저해활성 검색 (VI)
2011 KIOM-79 inhibits aldose reductase acrivity and cataractogenesis in Zucker diabetic fatty rats
2010 중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (IV)
2010 Scopoletin from the flower buds of magnolia fargesii Inhibits Protein Glycation , Aldose Reductase , and Cataractogenesis Ex vivo
2010 Single step separation of bioactive flavonol glucosides from Osteomeles schwerinae by high-speed counter-current chromatography
2010 Anti-obesity effect of Morus bombycis root extract: anti-lipase activity and lipolytic effect.
2010 Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro.
2010 Inhibition of aldose reductase and xylose-induced lens opacity by puerariafuran from the roots of pueraria lobata
2010 Anthraquinones from the Roots of Knoxia valerianoides Inhibit the Formation of Advanced Glycation End Products and Rat Lens Aldose Reductase in vitro
2009 KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats
2009 중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (III)
2009 Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa).
2009 Flavan-3-ols Having a gamma-Lactam form the Roots of Actinidia arguta Inhibit the Fornation Glycation End Products in Vitro.
2009 3,5-Di-O-caffeoyl-epi-quinic Acid from the Leaves and Stems of Erigeron annuus Inhibits Protein Glycation, Aldose Reductase, and Cataractogenesis.
2009 Flavan-3-ols Having a gamma-Lactam from the Roots of Actinidia arguta Inhibit the Formation of Advanced Glycation End Products in Vitro

특허

주요 연구 실적 표-주요 연구실적에 대하여 연도, 발명의 명칭, 비고 안내
연도 발명의 명칭
2017 (계지목단피)-천연 추출물 (2014-Ⅴ)을 포함하는 혈액부종의 예방 또는 치료용 약학적 조성물 및 건강기능식품 조성물
2016 천연 추출물 (2014-Ⅴ)을 포함하는 혈액부종의 예방 또는 치료용 약학적 조성물 및 건강기능식품 조성물
2016 석류풀 추출물을 유효성분으로 함유하는 관절염의 예방, 개선 또는 치료용 조성물
2016 관중 추출물을 유효성분으로 함유하는 고요산혈증 또는 고요산혈증 관련 대사 장애의 예방, 개선 또는 치료용 조성물
2016 (계지작약)-당뇨병성 망막증-천연 추출물 (2014-Ⅴ)을 포함하는 혈액부종의 예방 또는 치료용 약학적 조성물 및 건강기능식품 조성물
2016 고요산혈증 및 고요산혈증 관련 대사 장애 예방 및 치료효과를 갖는 총백추출물
2016 고요산혈증 및 고요산혈증 관련 대사 장애 예방 및 치료용 익지인 추출물
2015 천연 추출물을 포함하는 당뇨합병증의 예방 또는 치료용 약학적 조성물 및 건강기능식품 조성물
2015 천연 추출물 (2014-I)을 포함하는 당뇨합병증의 예방 또는 치료용 약학적 조성물 및 건강기능식품 조성물
2015 천연 추출물 (2014-Ⅱ)을 포함하는 혈액부종의 예방 또는 치료용 약학적 조성물 및 건강기능식품 조성물(작약, 또는 작약 및 감초 혼합 추출물을 유효성분으로 함유하는 혈관부종 예방 또는 치료용 약학적 조성물 )